Chloroform is a human chemical countermeasure. Sam and Dean use it against Doc Benton because his immortality is scientific, not magical, and ordinary incapacitation still affects him.

Devil's shoestring is a protective herb used to hold hellhounds at bay. It can delay the threat, but Bela's fate proves that a barrier is not the same thing as breaking a crossroads contract.

A devil's trap does not kill a demon. It contains one. As long as the symbol remains intact, most demons cannot cross its boundary and lose access to many of their powers. Break one line, however, and the…

Ruby's demon-killing knife gave the Winchesters a way to kill most demons permanently, but every use carries rules and consequences. It usually kills the possessed vessel, fails against the strongest classes of demons, and cannot kill angels or…

Samuel Colt built this supernatural revolver in 1835 and made thirteen original bullets for it. The Colt can kill most supernatural beings and unlock the Devil's Gate, but Lucifer confirms that five things are beyond its power. The…